In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes
نویسندگان
چکیده
منابع مشابه
Characteristic gene expression profile of nuclear receptor superfamily induced by hepatotoxic and antimetabolic drugs in human primary hepatocytes
We evaluated the effect of 19 hepatotoxicants and 20 antimetabolites on the expression of genes of the human nuclear receptor (NR) superfamily in human primary hepatocytes, utilizing NR superfamily-related data extracted from the toxicogenomics database Open TG-GATES. A considerable number of the drugs alone induced a significant fold change in the expression of a large number of NRs. The membe...
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The use of cultured primary hepatocytes within toxicology has proven to be a valuable tool for researchers, however, questions remain with regard to functional differences observed in these hepatocytes relative to the intact liver. Cultured hepatocytes have typically been described as dedifferentiated, a classification based upon the investigation of a few key cellular processes or hepatocellul...
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ژورنال
عنوان ژورنال: Journal of Applied Toxicology
سال: 2008
ISSN: 0260-437X,1099-1263
DOI: 10.1002/jat.1328